Intersection of Sex and Gender Influences on Health and Disease R01 Grant

Purpose

The purpose of this Funding Opportunity Announcement (FOA) is to solicit R01 applications on the influence and intersection of sex and gender in health and disease, including: (1) research applications that examine sex and gender factors and their intersection in understanding health and disease; and (2) research that addresses one of the five objectives from Strategic Goal 1 of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research "Advancing Science for the Health of Women." The awards under this FOA will be administered by NIH ICs using funds that have been made available through the Office of Research on Women’s Health (ORWH) and the scientific partnering Institutes and Centers across NIH.

Research Objectives and Scope

This announcement solicits research to target gaps in knowledge regarding the influence and intersection of sex and gender on disease conditions to improve our understanding of the factors and mechanisms underlying sex differences in health. The primary objectives of this announcement include: (1) research applications that examine sex and gender factors and their intersection in understanding health and disease; and (2) research that addresses one of the five objectives from Strategic Goal 1 of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research.

To be responsive to this FOA, applications must address each of the following three variables, and their intersection, in the context of advancing a better understanding of health and disease and as relevant to the current research investigation:

(1) Sex-based variables: including but are not limited to anatomical and physiological traits that include external genitalia, secondary sex characteristics, gonads, chromosomes, and hormones, evaluation of sex as a biological variable; sex-based comparisons on conditions in females and males; or biomarkers.

(2) Gender-based variables: Including but not limited to social, environmental, cultural, and behavioral factors including gender identity, as an element of a person’s individual identity; or gender expression.

(3) One of the five objectives from Strategic Goal 1 of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research.

Awards: $3 million to fund up to 7 awards per receipt date

Deadline: 11/22/2023 and 11/22/2024

Award ID: RFA-OD-22-028

See the full announcement here.